RAF Typhoon FGR4s have joined forces with France's air force in a coordinated attack on an subterranean weapons facility in Syrian territory used by the IS group, according to the British defence ministry.
The site, located using surveillance, was thought to be housing weapons and explosive materials, the announcement noted, and was positioned in hills just above the ancient city of Palmyra in the heart of Syria.
"Our aircraft used laser-guided Paveway IV weapons to target a series of entry passages providing entry to the site... initial indications are that the target was engaged successfully," the MoD said.
There was no evidence of any civilian impact in the attack late on Saturday and each participating jet returned to base without incident, the ministry further stated.
The Typhoon FGR4s were supported by a Voyager refuelling tanker.
The Islamic State group - also known as Daesh - enforced militant control over large swathes of Iraq and Syria prior to its 2019 collapse.
"This action demonstrates the UK's leading role, and resolve to work closely with allied nations, to eradicate any resurgence of IS and their violent and radical beliefs in the Middle East," UK Defence Secretary the minister stated.
RAF aircraft have conducted patrols over Syrian airspace to "forestall any efforts to regroup" of IS subsequent to its defeat at the climactic battle in Baghuz in 2019, the authorities noted.
"I extend gratitude to the personnel of our armed forces involved in this mission for their expertise and their valour," Healey said. "They were part of a great many British personnel stationed over the festive period. This mission, to take out terrorist threats who endanger our security, demonstrates how our armed forces are prepared to act, all year round, protecting the UK domestically and influential overseas."
During December, the United States armed forces conducted what it called a "large-scale strike" against Daesh sites in Syria, following an assault killed two American soldiers and a civilian linguist in the Palmyra area.
The United Nations says IS still boasts an estimated 5,000 to 7,000 militants in Syria and Iraq.